What is Pott’s Disease/spinal tuberculosis?

Tuberculosis is generally preventable and curable under the right conditions.

Overview:

Spinal tuberculosis or tuberculosis spondylitis also known as Pott’s disease is a spinal infection caused by tuberculosis.

Symptoms of spinal tuberculosis are kyphotic deformity, osteomyelitis, and spinal mechanical instability.

Diagnosis is made with CT-guided biopsy test for microscopic examination of acid-fast bacilli and this microscopic examination is called Acid-fast staining.

Treatment is generally, practiced with formulated based on the absence or presence of neurological involvement. Whereas with complicated TB spine patients, surgical invention is needed with the addition of chemotherapy.                    

Tuberculosis and Pott’s disease/spinal tuberculosis:

Tuberculosis (TB) is an exceedingly infectious disease, especially in immuno-suppressed populations caused by the bacterium, Mycobacterium tuberculosis which initially infects the lungs. Still, in some cases, it can spread to other parts of the body. When tuberculosis spreads, it’s referred t as extra-pulmonary tuberculosis (EPTB).

Joints and bones tuberculosis is one form of EPTB.

Tuberculosis is the 13th primary cause of death worldwide and it is the second main infectious cause of death, after COVID-19.  Most common in developing countries but increasing numbers of reported cases in developed countries as well.

Epidemiolog: 

According to the CDC (Centers of Disease Control and Prevention) in 2020, more than 7,000 cases were reported in the United States.

Unfortunately, the cases of spinal tuberculosis (as with the other form of TB) are arising due to the new multiple drug-resistant strains.

WHO (The World Health Organization) about 1.5 million people died from this disease in 2020. Whereas, 10.4 million new cases of tuberculosis were reported in 2016, among which 46.5 % of cases were reported alone from the South East Asia region. India contributed 23% of the worldwide tuberculosis load.

Osteomyelitis or Discitis usually affects the lower thoracic and upper lumber levels of the spine, comprising just about 50% of musculoskeletal TB.  

Etiolog: 

Pott’s disease or Spinal TB may develop when the air is contaminated with the TB-causing bacteria, Mycobacterium tuberculosis, and the person breath into the lungs. This infection can spread from the lung to the spine through the blood called hematogenous. A person who has an active TB infection can infect the air with aerosol droplets, by speaking, spitting, coughing, sneezing, etc. Each sneeze can spread approximately 40,000 aerosol droplets, and only a single droplet can spread the infection.

Some common risk factors for Tuberculosis are

• Pronged exposure to infected patients
• Overcrowding
• Malnutrition
• Immuno-deficiencies (due to HIV, alcohol, drugs)
• Lower socio-economic situations
• Poverty

 

Symptoms:

The symptoms or clinical presentation of spinal TB are inconsistent. The signs depend upon the

·    The severity of the disease

·    Duration of illness

·   Location of lesion

·  The presence of related complications includes neurological deficit and deformity.

Constitutional symptoms: 

Genuine or constitutional symptoms include

·         Loss of appetite

·         Significant weight loss

·         Fever

·         Malaise/fatigue

·         Night sweats

Symptoms of uncomplicated spinal tuberculosis:

In uncomplicated spinal infection patients generally feel back pain, and this back pain can be related to the active disease itself (secondary to inflammation), instability, and bone destruction. Rest pain is pathognomonic and rarely, radicular pain may be the main spinal tuberculosis symptoms.

Symptoms of complicated spinal tuberculosis:

In complicated spinal tuberculosis patients may present with instability, deformity, and neurologic deficit (present in 10-47% of patients).

Cold abscess;

These abscesses characteristically do not have all the inflammatory noticeable signs that are generally obvious in abscesses.

Deformity;

Unsettled with the greater involvement of the anterior spinal column in tuberculosis, the spinal column gradually develops a kyphosis, especially in the thoracic and thoracolumbar spine. 

Neurological Deficit;

A neurological deficit may arise either at the active stage of the disease resulting in compression from an abscess, spinal stability, sequestrum, or inflammatory tissue, or it may happen during the healed stage usually secondary to mechanical traction spinal defect.

Spinal tuberculosis in kids:

Children are more prone to developing severe deformity progression due to increased flexibility of the spine and immaturity in kids. These worsening deformities may also occur after the disease has completely healed, so follow-up is crucial until skeletal maturity.

Diagnosis:

Following tests are generally run for the diagnosis of Tuberculosis 

1.      Sputum culture

2.    X-rays

3.    Blood culture

4.    Mantoux tuberculin skin test

5.     Tissue biopsy (to check the possibility of cancer)

CT Scan; A computerized tomography (CT) scan is a medical technique to capture detailed internal images of the body.

This scan provides much better bony detail of irregular lytic lesions, disk collapse, disruption of bone circumference, and sclerosis than X-Rays. This scan discloses before-time lesions and much effective for defining the calcification of soft tissue abscess that is common Tuberculosis. 

MRI; Magnetic resonance imaging (MRI) is a medical imaging technique in which a strong magnetic field, radio waves, and magnetic field gradient are used to create images of the organ of the body. MRI is also considered the most effective imaging study for indicating neural compression. MRI is a valuable way of diagnosing certain diseases that a CT scan can’t detect.

Importance of MRI in diagnosis:

1.      MRI is the decisive factor for evaluating osteomyelitis and disk-space infection of the spine.

2.    MRI is also known as the most effective imaging study for indicating neural compression.

3.    This diagnostic technique is also most effective for demonstrating the spread of tuberculous debris under the posterior and anterior longitudinal ligament and the extension of disease into soft tissue.

4.    MRI results are useful to distinguish tuberculous spondylitis from pyogenic spondylitis comprise smooth and thin enhancement of the abscess wall and precise paraspinal abnormal signal, while irregular and thick enhancement of abscess wall and ill-defined paraspinal abnormal signal suggest pyogenic spondylitis.  Consequently, distinguish-enhancement MRI showed to be important in the differentiation of these two types of spondylitis.

Biopsy: is a medical procedure to remove a sample of cells or pieces of tissue from the body so that can be tested in a laboratory.

For the diagnosis of spinal tuberculosis percutaneous CT-guided biopsy of bone and lesions can be used to get tissue samples. The biopsy is a safe medical procedure that also allows therapeutic drainage of large paraspinal abscesses. 

PCR test: Polymerase chain reaction (PCR) technique magnify species-specific DNA sequences, that are able to rapidly identify and diagnose many strains of mycobacterium without the need for prolonged culture.

PCR tests have also been used in DNA sequences associated with drug resistance. 

ESR: Erythrocytes sedimentation rate (ESR) is done to measure how quickly red blood cells settled in the bottom of the test tube because infection or inflammation may lead to protein in the blood, which can facilitate red blood cells settling down faster. 

In patients with bone TB or Pott’s disease usually, ESR is elevated but may be normal in up to 25%. 

CBC: Complete Blood Count (CBC) blood test is done to evaluate a person’s overall health and detect a wide range of disorders including anemia. In males and females, there are different normal ranges.

Patients with spinal TB usually have low hemoglobin and relative lymphocytosis.

PPD: Purified protein derivative of tuberculin (ppd) is a skin test that determined if the patient has a serious TB infection.

Ppd test is usually 80% positive for spinal TB.

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Treatment:

The stronghold of treatment in spinal tuberculosis is chemotherapy, in which anti-tubercular treatment follows. Tubercle bacilli (Mycobacterium tuberculosis bacilli) may be present as extracellular or intracellular forms or rapidly multiply forms or as dormant. In order to reduce the instance of drug resistance and to attack the bacilli in various stages or forms, multi-drug treatment is very important.

It is very important to classify spinal tuberculosis as an uncomplicated and complicated disease, based on its appearance.

1. Uncomplicated spinal tuberculosis is basically a medical disease.
2. Complicated tuberculosis patients need surgical intrusion with the combination of chemotherapy

The first line of treatment for spinal TB or pott’s disease is the surgical removal of the tubercular infection. Administration of anti-tubercular medications (use of antibiotic) is done before and after the surgical procedure. This procedure is pursued by the surgical reconstruction o the spine.

The treatment protocol is prepared based on the absence or presence of neurological involvement. Usually, pharmacotherapy is preferred over surgery in case of neurological involvement. Pyrazinamide, Rifampicin, Isoniazid, and Etahmbutol drugs use as an anti-tubercular medications in pharmacotherapy.

With a safe and better response, surgery done during the active stage of infection/disease is much safer.

Physical therapy management:

Patients with spinal tuberculosis or pott’s disease often undergo spinal compression or spinal fusion surgeries to correct their structural deformity and prevent further neurological complications. There are no recognized guidelines that dictate the treatments that will defer positive effects in such patients. However, treatment schedules should deal with each patient individually, focal pointing to any injury functional restrictions, and/or disabilities with which they present.

Disease in children, the need for regular follow-up until skeletal maturity requires to be obviously communicated to the blood relations and the chance of progression of deformity still years after healing of the disease.

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 Physical Therapy Management Post-Spinal Decompression Surgery

1.      Exercise and strengthening

2.    Spinal Stabilization Exercise

3.    Back School

4.    Maitland

When evaluated with self-management spinal stabilization exercise and the other physical therapy treatments, self-spinal stabilization exercises were found to turn out considerably more positive ratings in worldwide outcomes. Disability and pain, however, did not show considerable improvement when measured up to the other two treatment options.

Physical therapy management post-spinal fusion surgery:

1.      Aquatic therapy

2.     Aerobic exercise

3.    TENS (Transcutaneous Electrical Neuromuscular Stimulation)

4.    Over-ground Training (Walking Program)

5.    Trunk Strengthening

Studies investigating the use of TENS have shown higher occurrences are

more effective in declining neuropathic pain. Aerobic exercise, trunk

strengthening, and PT interventions have all achieved a significant drop-off in

pain.

Education:

For patients with pott’s disease, it is very important to educate them about the management of this disease individually, as well as in the whole community.

1. Isolation of patients is crucial, especially those, who can spread the infection potentially is supreme.
2. Strict conformity for long-term chemotherapy is very important in order to complete diminished infection.
3. Disease in children, the need for regular follow-up until skeletal maturity requires to be obviously communicated to the blood relations and the chance of progression of deformity still years after healing of the disease.
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